The influence of endocardial endothelium on myocardial contraction
Article Abstract:
The mechanisms of action, physiology and pathophysiological relevance of endocardin and endothelium-derived relaxing factor were studied. Endocardin and endothelium-derived relaxing factor (EDRF) are both released from endocardial endothelium but have opposite effects, the former prolongs while the latter abbreviates myocardial contraction. In vitro and in vivo experiments demonstrate that the endocardial endothelium exerts both prolonging and abbreviating effects on myocardial contraction. Furthermore, the endocardial endothelium is shown to alter inotropic responses to different agonists.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Myocardial preconditioning as the heart's self-protecting response against the consequences of ischaemia
Article Abstract:
An initial ischaemic stimulus preconditions the myocardium and increases the heart's tolerance for further damage. Myocardial preconditioning reduces infarct size, decreases arrhythmia and degree of myocardial stunning through various mechanisms. The initial preconditioning occlusion must be between one and five minutes in duration and the period of reperfusion must exceed one minute. Proposed mechanisms of preconditioning include the release of adenosine and endogenous cardioprotective substances such as prostacyclin, nitric oxide and bradykinins.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Low-frequency components of cardiovascular variabilities as markers of sympathetic modulation
Article Abstract:
A study was conducted to characterize the action of the low-frequency components of cardiovascular variabilities on the dynamics of the sympathetic and vagal balance using autoregressive spectral analyses. Results showed that the two major rhythms involved in heart rate variability reflects the balance between sympatho-vagal activities. They also showed a correlation between the activity in vasomotor tone and the low-frequency component of systolic arterial pressure.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Frequency use of botanicals. Fragrance stability in three cosmetic applications
- Abstracts: Endothelin: a knockout in London. California dreamin' 'bout endothelin: emerging new therapeutics. The Institute of Pharmacology of Sherbrooke: a first in Canada
- Abstracts: Physiological basis of multicompartmental models of drug distribution. The genetic basis of malignant hyperthermia
- Abstracts: Anthranoid laxatives and colorectal cancer. Nucleoside diphosphate kinases as potential new targets for control of development and cancer
- Abstracts: Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities. part 2 Neuropeptides and nociception: recent advances and therapeutic implications