Forging a path to cell death

Article Abstract:

Understanding of the signalling paths of cell death received a boost in 1995 with the revelation of the function of an amino-acid sequence known as the 'death domain' in apoptosis-associated proteins. The new knowledge could lead to Cancer therapies or a deeper understanding of the immune system.

Cellular signal transduction

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Death gives birth to the nervous system. But how?

Article Abstract:

Neuroscientific research has focused in the past on why cells live or die during the development of the nervous system, rather than on how they die. Neuronal death expert Eugene Johnson has made an important contribution by studying how cells die.

Nervous system, Johnson, Eugene

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Death by dozens of cuts

Article Abstract:

Scientists are gaining understanding of the workings of caspases, which are protein-cutting enzymes important to apoptosis. Knowledge of caspases may someday aid in intervening in apoptosis that goes awry because of diseases such as cancer.

Enzymes, Enzyme regulation

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