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Genetic analysis of complex diseases

Article Abstract:

Neil Risch and Kathleen Merikangas conducted a series of studies on human disease-risk gene screening based on transmission-equilibrium test and sib-pair linkage analysis. Improvements, comments and suggestions to those studies are presented.

Author: Pericak-Vance, Margaret A., Haines, Jonathan L., Scott, William K., Merikangas, Kathleen, Risch, Neil, Langley, Charles H., Abel, Laurent, Long, Anthony D., Bell, Douglas A., Taylor, Jack A., Grote, Mark N., Muller-Myhsok, Bertram
Publisher: American Association for the Advancement of Science
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1997
Genetic screening, Genetic testing

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The future of genetic studies of complex human diseases

Article Abstract:

Association studies have greater potential than linkage studies in determining the genetic factors in complex diseases. Using association studies will require large-scale testing to identify the genes causing the disease.

Author: Merikangas, Kathleen, Risch, Neil
Publisher: American Association for the Advancement of Science
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1996
Methods, Medical genetics

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Genetic complexity and Parkinson's disease

Article Abstract:

The apparent chromosome locus identified in a study of Parkinson's disease (PD) may not be responsible for the majority of inherited idiopathic PD cases. Other studies indicate genetic heterogeneity in PD.

Author: Roses, Allen D., Pericak-Vance, Margaret A., Scott, William K., Stajich, Jeffrey M., Speer, Marcy C., Vance, Jeffrey M., Durr, A., Yamaoka, Larry H., Gasser, T., Muller-Myhsok, B., Wszolek, Z.K., Vaughan, J.R., Bonifati, V., Meco, G., Bereznai, B., Oehlmann, R., Agid, Y., Brice, A., Wood, N., Polymeropoulos, Mihael H.
Publisher: American Association for the Advancement of Science
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1997
Genetic aspects, Parkinson's disease, Parkinson disease

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Subjects list: Research, Genetic disorders
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