Pathomechanisms in channelopathies of skeletal muscle and brain

Article Abstract:

The pathogenic mechanisms of channelopathies affecting skeletal muscle and brain arising from mutations of voltage-gated ion channels and fast ligand-gated ion channels expressed at the surface membrane are explored. The analysis has provided insights on channel structure-function relations, the physiological roles of ion channels, and rational approaches toward therapeutic intervention for many disorders of cellular excitability.

Gene mutations, Gene mutation, Genetic aspects, Genetic research, Myotonia

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TRP ion channels and temperature sensation

Article Abstract:

The extent to which thermoreceptor potentials (TRPs), a subset of the transient receptor potential family of ion channels, are responsible for providing a molecular basis for thermal sensation is examined. Electrophysiological, molecular and loss-of-function studies have shown that thermoTRP channels play an integral part in thermal sensation over the entire range of temperature perception.

Electrophysiology, Temperature sensation

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Brain work and brain imaging

Article Abstract:

Functional brain imaging with positron emission tomography and magnetic resonance imaging is used to map regional changes in brain activity. Neuroimaging, with its unique metabolic perspective, has pointed towards the ongoing and costly intrinsic activity within brain systems that represents the largest fraction of the brain's functional activity.

Usage, Brain, Magnetic resonance imaging, PET imaging, Positron emission tomography, Glycolysis

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