Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance

Article Abstract:

The understanding of the major families of axon guidance cues and their receptors, with a particular emphasis on receptor signaling mechanisms is summarized and reviewed. The advances in understanding receptor cross talk and the ways in which the activities of guidance cues and their receptors are modulated during neural development are also discussed.

Ligand binding (Biochemistry), Cytoskeleton

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Cell-cell signaling during synapse formation in the CNS

Article Abstract:

A study was conducted, in which several trans-synaptic signaling systems are identified that can mediate various aspects of synaptic differentiation in the central nervous system (CNS). It is shown that the normal nervous system function is ensured through individual pathways that functionally cooperate thereby generating robustness and flexibility.

Central nervous system, Dendrites

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Ubiquitin-dependent regulation of the synapse

Article Abstract:

Ubiquitin and ubiquitin binding proteins focusing on the machinery of ubiquitination and the function of ubiquitin modification is reviewed. The experimental evidence that ubiquitin nation is a potent regulator of the synapse is discussed.

United States, Proteolysis, Neural transmission, Synaptic transmission, Neuroplasticity, Ubiquitin-proteasome system

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