Commentary: aging, differentiation-dependent gene expression, and fat cell function

Article Abstract:

The key finding of Hotta et al (1999) is that aging is linked to the decline in the expression of transcription factors that control fat cell function and preadipocyte differentiation in whole fat tissue of rhesus monkeys. These changes in transcription factor expression may be linked to changes intrinsic to adipose cells or may be the result of hormonal changes that come with age. The results suggest that the link between aging and the activity of transcription factors such as PPAR-gamma and C/EBP(alpha) needs to be tested with pharmacological and molecular biological methods.

Gene expression, Genetic transcription, Transcription (Genetics), Cell differentiation, Adipose tissues, Adipose tissue, Monkeys as laboratory animals, Laboratory monkeys

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Effects of aging and caloric restriction on extracellular matrix biosynthesis in a model of injury repair in rats

Article Abstract:

Analysis of Fischer 344 rats of various ages implanted with polyvinyl alcohol sponges reveals a reduction in collagen production and accumulation in response to injury with aging. The chronic caloric restriction has severe effects on the healing of injuries, especially in aged animals. This caloric restriction causes a decrease in dihydroxylysinonorleucine and collagen production. The crosslinking in the granulation tissue is not affected, as revealed by a study of enzymatic crosslinks.

Collagen, Extracellular matrix

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Commentary on "Left ventricular response to beta-adrenergic stimulation in aging rats": the aging process of the heart

Article Abstract:

Aging may have different effects on the myocyte and non-myocyte components of the heart. A study on rats found that the hearts of old rats still responded to beta-adrenergic stimulation, suggesting that this response is preserved in old age.

Heart ventricle, Left, Left heart ventricle, Nervous system, Sympathetic, Sympathetic nervous system

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