Diet and the suitability of the male fischer 344 rat as a model for aging research

Article Abstract:

The suitability of the male Fisher 344 rat as laboratory animal for aging research was evaluated because of the high prevalence of severe nephropathy secondary to aging which may distort research data. A previous study revealed that the replacement of casein with soy protein decreases the advancement of the nephropathy. In this study, the occurence of severe nephropathy did not decrease when casein was replaced with lactalbumin. The study, likewise, showed that diet restriction studies with soy protein can be effectively managed in male Fisher rats and are excellent research animals when given soy protein as dietary source.

Evaluation, Gerontology, Rats as laboratory animals, Laboratory rats, Soybean cake and meal, Soybean feeds, Soybean meal as feed

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Dietary restriction alters characteristics of glucose fuel use

Article Abstract:

The life-span levels of plasma glucose and insulin in ad libitum fed and dietary restricted rats were studied to know whether the reduction of energy intake per animal modulates the aging process by altering the characteristics of fuel use rather than the rate of use. Although results showed that dietary restricted rats maintained lower plasma glucose concentration and plasma insulin levels compared with the rats fed ad libitum, these do not validate the hypothesis of variable fuel use in aging.

Glucose metabolism

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Temporal pattern of food intake not a factor in the retardation of aging processes by dietary restriction

Article Abstract:

Male Fischer 344 rats, classified into various groups according to their dietary intake, serve as specimens for an analysis of the effects of food intake on the aging process. The antiaging action is affected by the temporal pattern of food intake, while there is a change in the circadian rhythms of food-restricted rats. The concentration of plasma glucose and the diurnal pattern of plasma corticosterone concentration vary among the different groups studied.

Diet, Ingestion

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