A cytokine-responsive I-kappa-B kinase that activates the transcription factor NF-kappa-B

Article Abstract:

Protein kinase activity activated by tumour-necrosis factor (TNF) and phosphorylates I-kappa-B-alpha at S32/36 has been identified in extracts of TNF-treated HeLa cells. The substrate specificity and kinetics of activation were well aligned with those of phosphorylation in living cells. It was possible to determine a partial peptide sequence for one of the components of this activity, a protein kinase with associated I-kappa-B activity quickly stimulated by proinflammatory cytokines. This protein kinase, IKK-alpha, is vital for NF-kappa-B activation in the presence of proinflammatory cytokines.

Protein kinases, Phosphorylation

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Three distinct signalling responses by murine fibroblasts to genotoxic stress

Article Abstract:

All genotoxic stresses activates the p53 signalling pathway in murine fibroblasts, while Jun kinases (JNK) and c-Abl are stimulated only by specific DNA-damaging agents. Except for ultraviolet light, all stimuli activate c-Abl. The activation of c-Abl occurs in the S-phase of the cell cycle and fails to affect cell proliferation. Only ultraviolet light and methyl methanesulphonate activate JNK. The activation of JNK by the alkylating agent is normal in c-Abl-null cells and reduced in the c-Src-null cells.

Fibroblasts, Genetic toxicology

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Mammalian MAP kinase signalling cascades

Article Abstract:

Research is presented concerning the influence of mitogen-activated kinases in the regulation of the physiological processes of cells. The signalling cascades which control cell proliferation, gene expression and cell death are discussed.

Cell death, Eukaryotic cells, Cells (Biology), Eukaryotes, Enzymes

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