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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Transformation from committed progenitor to leukemia stem cell initiated by MLL-AF9

Article Abstract:

Leukaemia stem cells (LSC) are shown to maintain the global identity of the progenitor from which they came while activating a limited stem cell or self-renewal-associated programme. The results have defined the progression from normal progenitor to cancer stem cell and have suggested that targeting a self-renewal programme expressed in an abnormal context might be possible.

Author: Golub, Todd R., Hahn, William C., Armstrong, Scott A., Gilliland, D. Gary, Jing Wang, Krivtsov, Andrei V., Twomey, David, Zhaohui Feng, Stubbs, Matthew C., Yingzi Wang, Faber, Joerg, Levine, Jason E.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
United States, Health aspects, Diagnosis, Leukemia

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Wnt signalling in stem cells and cancer

Article Abstract:

Canonical Wnt cascade is a critical regulator of stem cell and is also associated with cancer cells. Wnt pathway plays an integral role in maintenance and growth of stem cell as well as cancer cell in the intestinal, epidermal and haematopoietic systems.

Author: Reya, Tannishtha
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Cancer cells

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Subjects list: Research, Stem cells
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