A human Mad protein acting as a BMP-regulated transcriptional activator

Article Abstract:

Human Smad1 gene is a homologue of the Mothers against decapentaplegic and Sma genes, and induces transcription in the presence of the cytokine, bone-morphogenetic-protein 4 (BMP4). The GAL4-Smad1 gene construct activates transcription. BMP4-signals increase transcription and act through the BMP-receptor types I and II. The transcription activity is due to the C-terminal region in the absence of the N-terminal region. Smad1 encoded protein is involved in BMP signaling as its overexpression in the Xenopus embryo animal cap induces ventralization of the mesoderm.

Physiological aspects, Genetic regulation, Gene expression, Cytokines

---

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

Article Abstract:

Cell proliferation, apoptosis and differentiation is controlled and regulated by bone morphogenetic proteins (BMPs), TGF-beta and related factors, which are involved in signalling networks. Such signalling involves the antagonistic or synergistic interaction of different pathways. The mechanisms concerned with such agonistic interplay is ill understood. A study of the tumour-suppressor SMAD protein SMAD1, which moderates BMP signals, shows that it is a target of growth-factor signalling via the Erk MAP pathway. Details of the study are presented.

Proteins

---

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway

Article Abstract:

Transforming growth factor-beta (TGF-beta) and interferon-gamma (IFN-gamma) have opposing effects on cellular functions. TGF-Beta signals via a receptor serine kinase that activates transcription factors Smads 2 and 3, while the IFN-gamma receptor mediates activation of transcription factor Stat1. A basis for the integration of TGF-Beta and IFN-gamma signals is presented, suggesting a mechanism of transmodulation between STAT and SMAD.

Similar abstracts:

• Abstracts: Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
• Abstracts: Anecdotes, training, trapping and triangulating: do animals attribute mental states? Self-recognition in primates: further reflections create a hall of mirrors
• Abstracts: DNA fingerprinting reveals a low incidence of extra-pair fertilizations in the lesser kestrel. Copulatory behaviour and paternity determined by DNA fingerprinting in kestrels: effects of cyclic food abundance
• Abstracts: Eph receptors and ephrins restrict cell intermingling and communication. Function of the Eph-related kinase rtk1 in patterning of the zebrafish forebrain
• Abstracts: Role of the thrombin receptor in development and evidence for a second receptor. Thrombin signalling and protease-activated receptors

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.