A new subunit of the cyclic nucleotide-gated cation channel in retinal rods

Article Abstract:

An investigation of the structure of the cyclic guanylic acid-gated cation channel in retinal rods is reported. Cloning procedures succeeded in cloning a protein from human retina that had 30% overall identity to the rod channeel subunit. The eprotein localizes to rod outer segments, but of itself cannot form a functional channel. Co-expression of the protein with human rod channel protein in functional cation channel. These results indicate that the protein is a key subunit of the cyclic guanylic acid-gated cation channel in retinal rods.

Proteins, Retina, Protein structure

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From horsehair to lightning rods

Article Abstract:

Analogical reasoning played a key role in Benjamin Franklin's natural philosophy. He found it hard to visualize accumulations without compensatory deficits, reflecting the extent to which his thinking was influenced by the mode of thought that devised the concept of electricity plus and minus. Many of his contributions to natural philosophy, including his hypothesis about the identity of lightning and ordinary electricity, derived from analogies.

Influence, Philosophers, Franklin, Benjamin

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Unitary anion currents through phospholemman channel molecules

Article Abstract:

Measurement of unitary anion currents reveals that a 72-amino acid peptide, phospholemman (PLM) is involved in volume regulation. The peptide possesses a single transmembrane domain which generates ion channels. In Xenopus oocytes the expression of PLM enhances the flux of radiolabelled taurine. PLM is the smallest cell membrane protein that generates an ion channel.

Physiological aspects, Observations, Peptides, Oocytes, Oocyte donation

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