A nutrient-permeable channel on the intraerythrocytic malaria parasite
Article Abstract:
The transport properties of the two membranes separating the human malaria parasite Pplasmodium falciparum from the cytosol of its red blood cell host were investigated. The study is crucial to understanding how the parasite volume increases 25-fold during its 48-hour cycle inside the RBC, implying transport of large amounts of nutrients across the membranes. Cell-attached patch clamp studied of P. falciparum were perfomed. The results revealed the existence of a channel on the outer parasitophorous vacuole membrane, through which amino acids and monosaccharides are readily transported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Abnormal display of PfEMP-1 on erythrocytes carrying hemoglobin C may protect against malaria
Article Abstract:
A report on a marked effect of haemoglobin C on the cell-surface properties of Plasmodium falciparum-infected erythrocytes involved in pathogenesis is presented. Relative to parasite-infected normal erythrocytes parasitized AC and CC erythrocytes show reduced adhesion to endothelial monolayers expressing CD36 and intercellular adhesion molecule-1 (ICAM-1).
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite
Article Abstract:
The whole-cell voltage clamp method was used to study the permeability of red blood cells infected with the malaria parasite.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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