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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

SNAP receptors implicated in vesicle targeting and fusion

Article Abstract:

N-ethylmaleimide-sensitive fusion protein (NSF) is a membrane fusion protein which interacts with soluble NSF attachment proteins (SNAPs) during vesicle fusion. Since SNAPs bind to specific sites in membranes,an investigation was conducted to isolate and characterize SNAP receptors. Crude membrane fraction analysis identifed syntaxin, synaptobrevin and a hydrophilic SNAP-25 as SNAP receptors. It is proposed that these SNAP receptorscomprise part of a family of compartment-specific membrane proteins which function in the formation of correct vesicle-membrane attachments during fusion.

Author: Brunner, Michael, Rothman, James E., Sollner, Thomas, Whiteheart, Sidney W., Erdjument-Bromage, Hediye, Geromanos, Scott, Tempst, Paul
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
Identification and classification, Membrane proteins, Biological transport, Cell receptors

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A possible docking and fusion particle for synaptic transmission

Article Abstract:

The soluble N-ethylmaleimide-sensitive fusion (NSF) protein, alpha-soluble NSF attachment protein (SNAP) and beta-SNAP assemble to form a docking and fusion complex for synaptic transmission. Beta-SNAP binds to synaptotagmin and recruits NSF but alpha-SNAP is unable to do so. The complex probably associates the process of membrane fusion to the entry of calcium by attaching the fusion protein, beta-SNAP, to the calcium sensor, synaptotagmin.

Author: Sollner, Thomas H., Rothman, James E., Schiavo, Giampietro, Gmachl, Michael J.S., Stenbeck, Gudrun
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
Observations, Biosensors, Neural transmission, Synaptic transmission

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Subjects list: Research, Membrane fusion
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