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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Absence of excitiotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

Article Abstract:

Disruption of the gene encoding c-Jun amino-terminal kinase (JNK) 3 in mice was found to establish a resistance to the excitotoxic glutamate-receptor agonist kainic acid. Seizure activity was reduced and hippocampal neuron apoptosis was prevented. The observed neuroprotection was due to extinction of the Jnk3-mediated signalling pathway, which is significant in the pathogenesis of glutamate neurotoxicity.

Author: Whitmarsh, Alan J., Davis, Roger J., Flavell, Richard A., Zheng, Timothy S., Kuan, Chia-Yi, Rakic, Pasko, Yang, Derek D., Rincon, Mercedes
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
Cell death, Protein kinases, Hippocampus (Brain)

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

Article Abstract:

Interleukin (IL)-21 is shown as another cytokine that is highly expressed by mouse [CD.sub.4.sup.4+] helper T ([T.sub.H]) 17 cells. IL-21 is found to be an autocrine cytokine that is sufficient for [T.sub.H]17 differentiation and has served as a target for treating inflammatory diseases.

Author: Li Ma, Yongliang Zhang, Chen Dong, Nurieva, Roza, Xuexian O. Yang, Martinez, Gustavo, Panopoulos, Athanasia D., Schluns, Kimberly, Qiang Tian, Watowich, Stephanie S., Jetten, Anton M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
United States, Health aspects, Care and treatment, Polymerase chain reaction, Autocrine mechanisms, Cytokines, Inflammatory bowel diseases, Interleukin-21

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Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5

Article Abstract:

Innate and adaptive immune responses in the absence of MKP5 are examined. The study shows MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases.

Author: Davis, Roger J., Flavell, Richard A., Kennedy, Norman J., Greenberg, Philip D., Blattman, Joseph N., Ying Wang, Yongliang Zhang, Duong, Julie, Thang Nguyen, Chen Dong
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Immune response, Phosphatases, Immune response regulation

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