Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme

Article Abstract:

It has been possible to determine the crystal structure of granulocyte colony-stimulating factor (GCSF) complexed to the BN-BC domains, the main ligand-binding region of the GCSF receptor. The two receptor domains create a complex in a 2:2 ratio with the ligand. There is a non-crystallographic pseudo-twofold axis through mainly the inter-domain region and secondarily the BC domain. It is possible that two distinct orientations in the current GCSF-gs-cytokine receptor homologous complex are important in the formation of the fully active complex with the immunoglobulin-like domains from the partially active 2:2 complex.

Ligand binding (Biochemistry), Cytokines

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ATP receptor-mediated synaptic currents in the central nervous system

Article Abstract:

Adenosine 5'-triphosphate (ATP) is a fast neurotransmitter in the rat medial habenula. This identification was based on data from recordings of evoked and miniature synaptic currents in the habenula. The currents' fast rise time indicated that they were controlled by a ligand-activated ion channel such as ATP instead of by a second messenger system. This is the first evidence that synaptic currents in the central nervous system are directed by ATP receptors.

Physiological aspects, Identification and classification, Adenosine triphosphate, ATP, Neurotransmitters

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

Article Abstract:

Research on central nervous system metabotropic glutamate receptors and glutamate recognition is examined in detail.

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