Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

Article Abstract:

In vivo analyses to study the functions of receptor tyrosine kinases, Tie-1 and Tie-2, during vascular endothelial cell growth and differentiation indicate distinct, important roles for these structurally related receptors in the formation of blood vessels. Homologous recombination was used to make targeted mutations of these receptors' genes in mice. Tie-1 deficient mice were unable to structurally stabilize their vascular endothelial cells, resulting in localized hemorrhage and oedema. Tie-2 deficient mice had defective vasculogensis and low endothelial cell survival rates.

Neovascularization, Embryology, Experimental, Embryological research, Vascular resistance, Vascular endothelium, Tyrosine

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For whom the bell tolls

Article Abstract:

Danish physician Christian Gram discovered in 1884 that the outer membranes of bacteria could be classed as Gram negative of Gram positive. Gram negative organisms have a complex glycolipid lipopolysaccharide (LPS) or endotoxin, in their outer membranes. Yang and colleagues demonstrate that a cell-surface receptor, toll-like receptor 2 (TLR2) may play a part in the recognition of trace quantities of the glycolipid and the signals needed for the production of toxic cytokines transduced.

Bacterial infections, Glycolipids

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A role for the C3a anaphylatoxin receptor in the effector phase of asthma

Article Abstract:

Genetic deletion of the C3a receptor in a murine model of allergic airway disease, is found to protect against changes in lung physiology occurring following allergen challenge.

Asthma

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