Boc is a receptor for sonic hedgehog in the guidance of commissural axons
Article Abstract:
A study was conducted to show that two Robo-related proteins, Boc and Cdon, bind specifically to sonic hedgehog (Shh) and are therefore candidate receptors for the action of Shh as an axon guidance ligand. RNA-interference mediated knockdown of Boc impairs the ability of rat commissural axons to turn towards an ectopic source of Shh in vitro which suggests that Boc is essential as a receptor for Shh in commissural axon guidance.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
En passant neurotrophic action of an intermediate axonal target in the developing mammalian CNS
Article Abstract:
Spinal commissural neurons rely on trophic support from the floor plate of the spinal cord. The neurons develop extra trophic requirements after sending their axons along the floor plate for several days. This helps faulty neurons to be eliminated quickly and could stop straying neuronal circuits from being formed when the nervous system is being developed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Defining brain wiring patterns and mechanisms through gene trapping in mice
Article Abstract:
Research is presented concerning the development of a technique which makes use of an axonal marker to identify autonomous mechanisms, within the brain cells of mice, which are used in axon guidance.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: An exceptionally preserved vermiform mollusc from the Silurian of England. A Silurian sea spider
- Abstracts: Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Hedgehog signalling in the mouse requires intraflagellar transport proteins
- Abstracts: p[15.super.Ink4b] is a critical tumour suppressor in the absence of p[16.super.Ink4b]. Loss of p16inka4a confers susceptibility to metastatic melanoma in mice
- Abstracts: 'I have reported on astonishing achievements in times of hardship.'. Funding forces fusion project out of Europe
- Abstracts: Forest fire prediction and prevention in the Brazilian Amazon. Rethinking tropical forest conservation: Perils in parks