Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

Article Abstract:

Research describing the role of the vesicle transport protein Rab23 is presented. In particular its association with the mouse open brain and sonic hedgehog genes is investigated.

Molecular biology, Embryology, Animal embryology

---

Hedgehog signalling in the mouse requires intraflagellar transport proteins

Article Abstract:

Results show that intraflagellar transport proteins, Wim, Polaris, and the motor protein Kif3a are essential for Hedgehog signalling as shown by gene mutational studies in mice. Data indicate that disruption of genes of the intraflagellar transport proteins affect signal transduction.

United States, Analysis, Physiological aspects, Gene mutations, Gene mutation, Genetic aspects, Carrier proteins, Transport proteins, Cellular signal transduction, Flagella (Microbiology), Flagella

---

Regulated nuclear import of Rel proteins in the Drosphila immune response

Article Abstract:

The immune response of the Drosphila is similar to the mammalian innate response system. The Dif and Dorsal proteins move from the cytoplasm into the fat-body cells. The Toll signalling pathway controls the nuclear import of the Dorsal protein but research has shown that the Toll pathway is not needed for the import of Dif. The import of Dif and Dorsal results in the degradation of cactus protein therefore is it likely that there are two pathways which can distinguish between Dorsal and Dif. Mutations of three new genes have been identified.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Scientific Research and Development Services, Immunology, Research & Development-Universities, Drosophila, Immune response, University research

Similar abstracts:

• Abstracts: Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. ICOS is essential for effective T-helper-cell responses
• Abstracts: Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Progenitor cells from human brain after death
• Abstracts: Optical alignment and spinning of laser-trapped microscopic particles. Dynamical tunnelling of ultracold atoms
• Abstracts: Discovery of a metastable pi-state in a superfluid 3He weak link. Quantum interference of superfluid 3He
• Abstracts: Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.