Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel

Article Abstract:

A complimentary DNA from the nervous tissue of the snail, Helix aspersa, encodes the protein, Phe-Met-Arg-Phe-NH2 (FMRFamide)-activated sodium channel. Amiloride inhibits the channel. The sequence of the protein is different from another cloned epithelial Na+ channel subunits and Caenorhabditis elegans degenerins, but the structural organization is similar. FMRFamide stimulates a depolarizing response in the neurons of Helix on activation of the amiloride-sensitive Na+ channel.

Research, Usage, Observations, Cloning, Neurons, Sodium channels, Snails

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A proton-gated cation channel involved in acid-sensing

Article Abstract:

Acid-sensing is involved in nociception as well as taste transduction. Acidosis produces painful conditions which are thought to be secondary to hydrogen-gated cation channels found in sensory neurons. An acid-sensing ionic channel which is a member of amiloride-sensitive sodium channel/ degenerin family of ion channels was cloned. Rapid extracellular acidification temporarily activates the amiloride-sensitive cation channel induced by the acid-sensing ionic channel.

Ion channels

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K(sub v)LQT1 and IsK (minK) proteins associate to form the I(sub Ks) cardiac potassium current

Article Abstract:

The K(sub v)LQT1 complementary DNA and the cardiac protein IsK (minK) form the important channel I(sub Ks) involved in the cardiac potassium current. The LQT1 gene plays a role in the LQT syndrome involving ventricular arrhythmias. The I(sub Ks) cardiac channel has a slow current, whereas the I(sub Kr) cardiac channel has a rapid current. Both the currents are important targets of the class-III anti-arrhythmic drugs due to their importance in the LQT syndrome.

Physiological aspects, Potassium channels, Arrhythmia

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