Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells

Article Abstract:

Rod transducin was believed to be exclusively in the photoreceptor cells but has been found in vertebrate taste cells where it activates a phosphodiesterase isolated from the taste tissue. Denatonium, a bitter compound, in the presence of taste-cell membranes activates transducin but not Gi protein and a seven-transmembrane-helix G-protein-coupled receptor is most likely involved because taste-cell activation is inhibited by the same peptide as rhodopsin activation. Taste receptors are probably coupled to taste-cell phosphodiesterase through a rod transducin allowing for the transduction of bitter taste.

Taste buds, Rhodopsin, Chemical senses, Chemoreception

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Transduction of bitter and sweet taste by gustducin

Article Abstract:

Behavioral and electrophysiological response studies on mice, deficient in alpha-gustducin, demonstrates the mediatory role of gustducin in both bitter and sweet signal transduction. Mutation studies on the mice show reduced responses to bitter compounds and wild-type responses to salty and sour stimuli. However, the mice also exhibit reduced responses to sweet compounds. Gustducin is a taste receptor cell (TRC)-specific G protein with close links to the transducins. Gustducin and rod transducin couple bitter-responsive receptors to TRC-specific phosphodiesterases.

Cellular signal transduction, Mice, mutant strains, Mutant mice, Phosphodiesterases

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A cyclic-nucleotide-suppressible conductance activated by transducin in taste cells

Article Abstract:

Peptides derived from transducin's phosphodiesterase- interaction region generate an inward whole-cell current in a subset of frog taste cells. Both IBMX and forskolin were able to reversibly suppress peptide effects which indicates a transducin-activated phosphodiesterase. Cyclic-nucleotides may regulate taste-cell conductance as indicated by suppression of whole-cell currents by cyclic nucleotides.

Physiological aspects, Nucleotides

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