Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

Article Abstract:

LIM-kinase 1 (LIMK-1), a serine/threonine kinase containing LIM and PDZ domains, plays a role in Rac-mediated actin cytoskeletal reorganization. There is a potential connection between Rac, LIMK-1, cofilin and actin-filament dynamics. Rac prompts the kinase activity of LIMK-1, which in turn leads to phosphorylation and inactivation of cofilin. It probably also prompts a fall in the rate of actin depolymerization. LIMK-1 activity may be localized to confined regions within the cell by the binding of LIMK-1 to F-actin.

Protein kinases, Cytoskeletal proteins

---

CRM 1 is responsible for intracellular transport mediated by the nuclear export signal

Article Abstract:

Cellular research demonstrates that nuclear export signal (NES) proteins are inhibited by the cytotoxin leptomycin B. The Xenopus oocyte protein p110 which specifically binds to intact NES has been identified as the evolutionarily conserved protein CRM1. Evidence suggests that CRM1 is crucial to the nuclear export of proteins in the cells of multicellular organisms.

Eukaryotic cells, Cells (Biology), Eukaryotes, Serum, Blood serum, Cell research, Cytological research

---

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

Article Abstract:

Research is presented concerning the purification of the protein kinase from M-phase extracts of Xenopus which phosphorylates a serine residue half way through the nuclear export signal sequence.

Physiological aspects, Proteins, Xenopus, Cytology, Phosphorylation, Letter to the Editor

Similar abstracts:

• Abstracts: Local population dynamics in metapopulation models: implications for conservation
• Abstracts: Foams flow by stick and slip. Diffusion in a different direction. Memories of paste
• Abstracts: A cytokine-responsive I-kappa-B kinase that activates the transcription factor NF-kappa-B. Mammalian MAP kinase signalling cascades
• Abstracts: Injection and detection of a spin-polarized current in a light-emitting diode. An efficient room-temperature silicon-based light-emitting diode
• Abstracts: An experimental replication of upper-mantle metasomatism. Redox evolution of a degassing magma rising to the surface

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.