Control of blood cell homeostasis in Drosophila larvae by the posterior signalling center
Article Abstract:
A small cluster of signalling cells, called the posterior signalling center (PSC), is used to control the balance between multipotent prohaemocytes and differentiating haemocytes and it is required for the massive differentiation of lamellocytes that follows parasitization. The key role of the PSC in controlling blood cell homeostasis has highlighted the interest of Drosophila as a model system for studying the evolution of haematopoiesis and cellular innate immunity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors
Article Abstract:
The posterior signalling centre (PSC) is specified early in the embryo by the homeotic gene Antennapedia (Antp) and has conveyed the signalling molecule Hedgehog. The results have shown the PSC functions as a haematopoietic niche that is required for the maintenance of blood cell precursors in Drosophila.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
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