Control of compartmental affinity boundaries by Hedgehog

Article Abstract:

Analysis of cell affinities in the developing wing of Drosophila shows a division into the anterior (A) and posterior compartments (P), mediated by the transcription factor Engrailed (En) in P cells. Under control of En, P cells secrete the signalling protein Hedgehog (Hh), to which they cannot respond. It is hypothesized that the failure of A and P cells to intermix is caused by the Hh secreted by the P cells. A mutation of the gene smoothened is used to show that the affinity boundary that segregates the A and P cells is mainly a consequence of local Hh signalling.

Genetic aspects, Cell interaction, Cell interactions, Wings (Animal), Animal wings, Cell compartmentation

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Induction and regulation of the IgE response

Article Abstract:

Atopic or allergic conditions are familiar diseases in Western societies. The complex regulation of the IgE response is examined. IgE production is closely linked to subtypes of T cells and their cytokine products, certain pathogens and allergens. Emerging concepts of IgE production and elimination should clarify the significance of IgE in health and disease.

Allergy

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