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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

Article Abstract:

Copy number variation of the orthologous rat and human Fcgr3 genes is a determinant of susceptibility to immunologically mediated glomerulonephritis. Positional cloning identifies loss of the rat-specific Fcgr3 paralogue, Fcgr3-related sequence as a determinant of macrophage overactivity and glomerulonephritis in Wistar Kyoto rats and in humans, low copy number of FCGR3B, is associated with glomerulonephritis in the autoimmune disease systemic lupus erythematosus.

Author: Aitman, Timothy J., Norsworthy, Penny J., Smith, Jennifer, Evans, David J., Rong Dong, Vyse, Timothy J., Johnson, Michelle D., Mangion, Jonathan, Roberton-Lowe, Cheri, Marshall, Amy J., Petretto, Enrico, Hodges, Matthew D., Bhangal, Gurjeet, Patel, Sheetal G., Sheehan-Rooney, Kelly, Duda, Mark, Cook, Paul R., Domin, Jan, Flint, Jonathan, Boyle, Joseph J., Pusey, Charles D., Cook, H. Terence
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
United States, Science & research, Causes of, Genetic polymorphisms, Glomerulonephritis, Human cloning

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Molecular analysis of the association of HLA-B53 and resistance to severe malaria

Article Abstract:

The human leukocyte antigen-B53 (HLA-B53) bolsters immunological defenses against the acute form of malaria caused by the parasite Plasmodium falciparum (P. falciparum). Research involving malaria-resistant Africans found that HLA-B53 assisted the cytotoxic T lymphocytes in attacking P. falciparum during the pre-erythrocytic phase of the parasite's life-cycle which occurs in the liver. HLA-B53 may eventually become a key part of a future antimalarial vaccine.

Author: Hill, Adrian V.S., Greenwood, Brian M., McMichael, Andrew J., Takiguchi, Masafumi, Elvin, John, Willis, Anthony C., Aidoo, Michael, Allsopp, Catherine E.M., Gotch, Frances M., Gao, X. Ming, Townsend, Alain R.M., Whittle, Hilton C.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
Physiological aspects, Malaria vaccine, Malaria vaccines

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Malaria susceptibility and CD36 mutation

Article Abstract:

Research is presented concerning the susceptibility of people of African origin to infection by Plasmodium falciparum which causes the severest form of malaria. The connection between CD36 mutation and susceptibility to the disease is discussed.

Author: Aitman, Timothy J., Cooper, Lisa D., Norsworthy, Penny J., Wahid, Faisal N., Gray, Jennefer K., Curtis, Brian R., McKeigue, Paul M., Kwiatkowski, Dominic, Greenwood, Brian M., Snow, Robert W., Scott, James, Hill, Adrian V.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Diseases, Genetic aspects, Malaria, Africans

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Subjects list: Research, Plasmodium falciparum
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