Interdomain communication regulating ligand binding by PPAR-gamma
Article Abstract:
The action of lipophilic hormones and ligands requires binding to receptors in the cell nucleus. Adipocyte differentiation is mediated by the nuclear hormone receptor PPAR-gamma (peroxisome proliferator-activated receptor), which also modulates inflammatory processes and insulin sensitivity cell proliferation. Ligands of PPAR-gamma have been suggested as potential cancer treatments. A new study shows that PPAR-gamma ligand binding is regulated by intramolecular communication between its carboxy-terminal LBD and its amino terminal A/B domain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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The PPAR-alpha-leukotriene B(sub 4) pathway to inflammation control
Article Abstract:
The dihydroxy fatty acid leukotriene B(sub 4) (LTB(sub 4)), a chemotactic agent, initiates and controls the inflammatory response by activating the transcription factors, peroxisome proliferator-activated receptor (PPAR). PPAR-alpha regulates the oxidative degradation of fatty acids and their derivatives. A feedback mechanism controls the duration of the inflammatory response and the clearance of LTB(sub 4) in the liver. This suggests that PPAR-alpha is involved in the development of anti- and pro-inflammatory reagents.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Roles of PPARs in health and disease
Article Abstract:
Peroxisome proliferator-activated receptors (PPARs) play a key role in the genetic regulation of complex pathways of mammalian metabolism. PPAR-gamma acts at the level of the adipose tissue and encourages lipogenesis under anabolic conditions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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