Crosstalk between G proteins and protein kinase C mediated by the calcium channel alpha(sub 1) subunit

Article Abstract:

Crosstalk between second messenger pathways is examined. It is shown that this effect can be observed at the level of the presynaptic Ca(2+)-channel complex. The protein kinase C (PKC)-dependent upregulation of calcium channel activity is found to be affected by the alpha(sub 1) subunit domain of I-II linker. Meanwhile, binding of G beta gamma to two sites in the I-II linker is shown to facilitate G-protein-dependent inhibition. Evidence indicates that the PKC-dependent phosphorylation of one of these two G beta gamma binding sites, which resist inhibition induced by G beta gamma, generates crosstalk.

Protein kinases, Crosstalk

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Cleavage of syntaxin prevents G-protein regulation of presynaptic calcium channels

Article Abstract:

The patch-clamp technique was applied to test whether calcium current is regulated by G proteins in a vertebrate presynaptic nerve terminal. It was also investigated whether the linkage to syntaxin has an impact on such regulation. Results revealed that the calcium current in the nerve terminal has typical G-protein-mediated changes in amplitude and activation kinetics. These suggest that the association of the presynaptic calcium channel with elements of the transmitter release site is necessary for the sensitivity of the current to G-protein regulation.

Neural transmission, Synaptic transmission

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Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem

Article Abstract:

Research into the role of G-proteins in the regulation of Ca2+ channels is presented, focusing on the GTP-bound form of kir/Gem.

Membrane proteins

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