Abstracts - faqs.org

Abstracts

Zoology and wildlife conservation

Search abstracts:
Abstracts » Zoology and wildlife conservation

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

Article Abstract:

Research is presented concerning the activity of the tumour suppressor p53 which will induce cellular senescence following stimulation by oncogenic signals. Acetylation, phosphorylation and protein stability modulate the activity of p53.

Author: Pearson, Mark, Carbone, Roberta, Sebastiani, Carla, Cioce, Mario, Fagioli, Marta, Saito, Shin'ichi, Higashimoto, Yuichiro, Appella, Ettore, Minucci, Saverio, Pandolfi, Pier Paulo, Pelicci, Pier Giuseppe
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Proteins, Phosphorylation, Oncology

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

Article Abstract:

Research into genotoxic stress and the initiation of G2/M checkpoints is described. It is shown that p38 kinase plays a major part in initiating a G2 delay following ultraviolet radiation.

Author: Higashimoto, Yuichiro, Appella, Ettore, Bulavin, Dmitry V., Popoff, Ian J., Gaarde, William A., Basrur, Venkatesha, Potapova, Olga, Fornace, Albert J., Jr.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Physiological aspects, Ultraviolet radiation, Letter to the Editor, Genetic toxicology

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

Article Abstract:

DNA damage in the cell activates p53, the tumour-suppressor protein. If this activation fails the result is genetic instability and a predisposition to cancer. The DNA-dependent protein kinase (DNA-PK) is thought to be a necessary activator of p53. The p53 response in primary mouse embryonic fibroblasts lacking DNA-PK was found to be fully functional. The results suggest that DNA-PK activity is not essential for cells to response to DNA damage.

Author: Saito, Shin'ichi, Appella, Ettore, Beeche, Michelle, Taccioli, Guillermo E., Jeggo, Penny A., Sakaguchi, Kazuyasu, Jimenez, Gretchen S., Bryntesson, Fredrik, Torres-Arzayus, Maria I., Priestley, Anne, Wahl, Geoffrey M., Hubank, Michael
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
Protein kinases, DNA polymerases

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, Tumors
Similar abstracts:
  • Abstracts: The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. The little devil of death
  • Abstracts: Aggression by polyembryonic wasp soldiers correlates with kinship but not resource competition. Competition induces adaptive shifts in caste ratios of a polyembryonic wasp
  • Abstracts: Condition-dependent signalling of genetic variation in stalk-eyed flies. Continual change in mate preferences
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2025 Advameg, Inc.