Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

Article Abstract:

The deficiency of CPP32/yama/apopain of the interleukin-1 beta converting enzyme family leads to a decrease in brain apoptosis and premature lethality in mice. The CPP32 is the mammalian homologue of the Caenorhabditis elegans cell death gene, ced-3. CPP32 deficiency affects brain development and leads to hyperplasis. It also leads to the formation of a supernumerary cell population during development. The CPP32 also plays an important role in the morphogenetic cell death taking place early in the central nervous system.

Analysis, Physiological aspects, Gene mutations, Gene mutation, Cell death, Mice, Mice (Rodents), Enzymes, Interleukin-1

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Discriminating migrations

Article Abstract:

A molecular cue guiding neurons as they move from the postnatal rodent forebrain into the olfactory bulb has been revealed by Wu and colleagues. The guidance mechanism is shown to depend on the brain structures around the migratory pathway. They propose that a protein from the Slit family may prevent neurons from the subventricular zone from entering septal territory well before the initiation of axonal connections.

Neurobiology, Proteins, Neurons

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Immigration denied

Article Abstract:

Two basic findings revealed from the investigations on a large number of postmortem and biopsy samples are presented. First finding states that, the neural stem cells are situated in a region of the forebrain known as the subventricular zone and the second one states that a pathway known, as the rostral migratory stream is absent in humans.

Science & research, Brain research, Stem cells, Cell proliferation, Astrocytes

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