Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
Article Abstract:
Positron emission tomography was used to study the distribution of D1 and D2 receptors in brains of drug-naive or drug-free schizophrenics. It was observed that binding of radioligand to D1R was lessened in the prefrontal cortex of schizophrenics, which was associated to the severity of negative symptoms and to poor performance in the Wisconsin Card Sorting Test. These findings suggest that dysfunction of D1R signalling in the prefrontal cortex may contribute to the negative symptoms and cognitive problems observed in schizophrenics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Modulation of memory fields by dopamine D1 receptors in prefrontal cortex
Article Abstract:
The role of dopamine in the cognitive process of functional memory has been established, but dopamine D1 receptors' effects in memory field modulation are still being determined. Research has shown that iontophoretic administration of drugs to the single-cell recording can influence behaviour significantly. D1 antagonists can activate the memory fields of some of the neurons in the prefrontal cortex that are responsible for furthering working memory.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Dopamine receptors get a boost
Article Abstract:
Research into the dopamine receptor molecule D3 has found that brain-derived neurotrophic factor (BDNF) regulates expression of the D3 receptor. Until now, the BDNF protein was thought to be necessary merely for the spread, maturation and survival of neurons.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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