Destabilizaiton of Beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
Article Abstract:
Reversed protocol, immunoprecipitation of Beta-catenin and immunoblot analysis for PS1, showed co-precipitation of Beta-catenin with the N and C terminal fragments of Ps1. This suggests that Beta-catenin occurs in one or more complexes having N and C terminal fragments of PS1. The function of the transcription factor Tcf mediating Beta-catenin signalling was studied to confirm the involvement of the Beta-catenin signalling pathway in the regulation of neuronal apoptosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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A firm base for drug development
Article Abstract:
New research and reports by Yan and colleagues and Sinha and colleages, describes the identification of the Beta-secretase, implicated in Alzheimer's diseases. Development of medication requires validated animal models and well defined molecular targets, and the disease-causing mutations were discovered in the amyloid precursor protein (APP), enabling animal models to be developed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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An inflammatory drug prospect
Article Abstract:
Issues are presented concerning the beneficial treatment of mice with Alzheimer's disease through the use of pharmaceuticals prescribed for the treatment of rheumatoid arthritis. The implications for humans are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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- Abstracts: Evolution of high mutation rates in experimental populations of E. coli. The population genetics of ecological specialization in evolving Escherichia coli populations
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