Directional guidance of neuronal migration in the olfactory system by the protein Slit
Article Abstract:
Neurons that develop in the nervous system must migrate to their final positions, but an understanding of the processes guiding neuronal migration is still limited. The olfactory system is useful in studying neuronal migration. Neuronal progenitors must migrate in the rostral migratory stream (RMS) from the subventricular zone (SVZa) of the telencephalon in rodents. It is shown that the septum repulses SVZa neurons in matrigel, and the expression of two slit genes in the postnatal septum encoded proteins that are repulsive cues able to guide SVZa cell migration.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
Article Abstract:
Dendritic cells have a key role in the induction of immune responses, allowing them to be used therapeutically against diseases such as cancer and viral infections. The cells are highly-efficient at capturing antigens and presenting them to the T cells in lymphoid organs. However, there is little understanding of how they target naive rather than activated T lymphocytes. Research shows that a C-C chemokine, derived from the dendritic cell, plays an important part in the triggering of immune responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors
Article Abstract:
Research is presented concerning the influence of a secreted protein named Slit in the inhibition of leukocyte chemotaxis which has been induced by factors of a chemotactic nature.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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