Parental-origin-specific epigenetic modification of the mouse H19 gene

Article Abstract:

Parental imprinting in the expression of the H19 gene in mouse embryos was examined. In normal embryos, the H190 gene expresses a developmentally regulated product of unknown function. The gene lies on chromosome 7 and is susceptible to trancriptional regulation by parental imprinting, causing the expression of the maternally inherited gene and suppression of the paternally inherited gene. The study protocol comparison of CpG methylation and nuclease sensitivity of chromatin in MatDi7 embryos with those of normal littermates. The results that the H19 promoter gene region is hypermethylated only in the paternal allele.

Genetic regulation, Genetic transcription, Transcription (Genetics), Genetic disorders

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Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

Article Abstract:

Mutations in the src and fyn genes were introduced into csk(super-) mutant background to study the role of activated Src family kinases in the csk(super -1) phenotype. The research revealed that src is partly epistatic to the csk gene while fyn is possibly redundant or unnecessary. The influence of the src on cortactin, tensin and paxillin hyperphosphorylation, focal adhesion kinase and the normal distribution of cortactin is discussed.

Genetic aspects, Mutation (Biology), Mutation, Phosphorylation, Cytoskeleton

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