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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Dominant influence of HLA-B in mediating the potential co-evolution o HIV and HLA

Article Abstract:

The study reported that variation in viral set point, in absolute CD4 count and, by inference, in rate of disease progression in the cohort, is strongly associated with particular HLA-B. Further, HLA-B gene frequencies in the population are those likely to be most influenced by human immunodeficiency virus (HIV) disease, consistent with the observation that B alleles evolve more rapidly than A alleles.

Author: Coovadia, Hoosen M., Walker, Bruce D., Kiepiela, Photini, Thobakgale, Christina, Day, Cheryl, Szinger, James, Mullins, James, Leslie, Alasdair J., Chetty, Senica, Korber, Bettem,, Klenerman, Paul, Honeyborne, Isobella, Ramduth, Danni, Rathnavalu, Prinisha, Moore, Corey, Pfafferott, Katja J., Hilton, Louise, Goulder, Philip J. R.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
HIV infection, HIV infections

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T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand

Article Abstract:

A demonstration states that increasing the dimensions of the T-cell antigen receptor histocompatibility antigens (TCR-pMHC) interaction by elongating the pMHC ectodomain greatly reduces TCR triggering without affecting TCR-pMHC ligation. A similar dependence on receptor-ligand complex dimensions is observed with artificial TCR-ligand systems that span the same dimensions as the TCR-pMHC complex.

Author: Choudhuri, Kaushik, Wiseman, David, Brown, Marion H., Gould, Keith, Merwe, P. Anton van der
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005

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Calcineurin sets the bandwidth for discrimination of signals during thymocyte development

Article Abstract:

The article provides insight into early calcineurin and nuclear factor of activated T cells (NFAT) signalling is presented. The mechanism produces a thymocyte development period of ERK (protein kinase) hypersensitivity, which allows very weak signals to induce positive selection.

Author: Crabtree, Gerald R., Neilson, Joel R., Winslow, Monte M., Gallo, Elena M., Cante-Barrett, Kirsten, Radermacher, Amy N., Ho Lena, McGinnis, Lisa, Iritani, Brian
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Calcineurin, Phosphotransferases

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Subjects list: Research, United States, HLA histocompatibility antigens, HLA antigens, Histocompatibility antigens, Antigen receptors, T cell, T cell antigen receptors, T cells
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