Drug delivery and targeting: When a pharmaceutical agent is encapsulated within, or attached to, a polymer or lipid, drug safety and efficacy can be greatly improved and new therapies are possible
Article Abstract:
The development of drug delivery systems that can accurately target drugs to specific body sites have only become practical in recent years. In one approach to polymer based drug delivery systems, the drug is entrapped within a solid polymer which is then injected or implanted in the body. For slow delivery, drugs are embedded in the polymers at concentrations that create a interconnecting pores. New methods being researched including pulmonary local delivery, and approaches to blood-brain barrier transport.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo
Article Abstract:
Antisense c-myb oligonucleotide restricts the build-up of carotid arterial smooth muscle cells in rats. Hence this antisense oligonucleotide, a synthetic gene product derived from the proto-oncogene c-myb, has two potential applications: clarifying the biological function of particular macromolecules and providing a basis for a new group of drugs for treating cardiovascular diseases. This is the first successful in vivo test of an antisense gene product.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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A controlled-release microchip
Article Abstract:
A solid-state silicon microchip is reported that is able to provide controlled release of chemical substances on demand. This occurs via electrochemical dissolution of thin anode membranes over microreservoirs filled with chemicals. Studies were undertake using gold and saline solution as the model electrode material and release medium, and controlled, pulsatile release of chemical substances was obtained.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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