Early events in the thymus affect the balance of effectors and regulatory T cells

Article Abstract:

A study questions the completeness of the interpretation that critical balance between effector and regulatory mechanism is highlighted by serious immunopathologies attributable to mutations in Foxp3, a transcription factor required for a major subset of regulatory T [T.sub.a] cells in cellular immunology. It is shown that without any obvious effect on T-cell receptor-mediated selection, the normal differentiation of mouse (gamma)(delta) TR cells into potent cytolytic and interferon-gamma-secreting effector cells is switched towards an aggregate regulatory phenotype.

Science & research, T cells, Cellular immunity, Immunopathology

---

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Article Abstract:

The presenilin-1 (PS1) gene is involved in gamma-secretase-mediated proteolytic cleavage of the C-terminal transmembrane fragments of the amyloid precursor protein following their generation by alpha- and beta-secretase(s). It is not likely that PS1 is the elusive gamma-secretase, or one of the gamma-secretases, as there is a lack of sequence identity or structural homology between PS1 and any proteinase domain known. It appears that clinical mutations of PS1 lead to a gain of the function of PS1 and are not a haplotype insufficiency.

Gene mutations, Gene mutation

---

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

Article Abstract:

Photoaffinity labelling of presenilin 1 and presenilin 2 by strong gamma-secretase inhibitors designed to act as transition state analogue inhibitors directed to the active site of an aspartyl protease is discussed. It is suggested that presenilin 1 and presenilin 2 could contain the active site of gamma-secretase.

Enzyme inhibitors

Similar abstracts:

• Abstracts: Words and rules in the human brain. Talk of genetics and vice versa. Survival of the clearest: There are now fossils to show how language evolved
• Abstracts: Neuronal position in the developing brain is regulated by mouse disabled-1. Molecular switches in lipid rafts
• Abstracts: The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Mutant weed breaks silence
• Abstracts: The melting curve of iron at the pressures of the Earth's core from ab initio calculations. Constraints on the composition of the Earth's core from ab initio calculations
• Abstracts: Molecular identification of microorganisms associated with parthenogenesis. Infectious parthenogenesis

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.