Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa-B

Article Abstract:

The polypeptide, p65/RelA, of NF-kappa-B in mice controls the inducible transcription and stability of the pathways controlled by NF-kappa-B. Mutant mice in which p65/RelA is absent die within 15 to 16 days of gestation and show nuclear fragmentation in the liver caused by apoptosis. The induction of messenger RNA for I-kappa-B-alpha, mediated by the tumor necrosis factor, and granulocyte/macrophage colony stimulating factor are not seen in these mutants. However, the basal amounts of these transcripts are unaffected, indicating the I-kappa-B proteins are regulated by the inducible expression and stability of I-kappa-B-alpha and I-kappa-B-beta being controlled by RelA.

Physiological aspects, Genetic aspects, Cell death, Polypeptides, Mice as laboratory animals, House mouse

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A phosphatase complex that dephosphorylates (gamma)H2AX regulates DNA damage checkpoint recovery

Article Abstract:

A three-protein complex (HTP-C, for histone H2A phosphatase complex) containing the phosphatase Pph3 that regulates the phosphorylation status of (gamma)H2AX in vivo and efficiently dephosphorylates (gamma)H2AX in vitro is described. The dephosphorylation of (gamma)H2AX by the HTP-C is essential for the efficient recovery from the DNA damage checkpoint.

Science & research, Analysis, DNA damage, Genetic regulation, Phosphorylation

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