Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

Article Abstract:

Mice lacking both the epidermal growth factor (EGF) and its receptor exhibit retardation in growth and epithelial immaturity as a result of which there are gastrointestinal, lung, skin and other disorders that are similar to human diseases after premature birth. EGF is responsible for opening of the eyelids and its receptor is a tyrosine kinase receptor that is found in large quantities in mammals. The receptor is activated when it binds EGF or transforming growth factor-alpha, that results in induction of cell differentiation and proliferation.

Physiological aspects, Cell differentiation, Embryology, Animal embryology, Epidermal growth factor, Epidermal growth factors

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Derivation of pluripotent epiblast stem cells from mammalian embryos

Article Abstract:

The derivation of pluripotent stem cells from the late epiblast layer of post-implantation mouse and rat embryos using chemically defined, activin-containing culture medium that is sufficient for long term maintenance of human embryonic cells is demonstrated.

Science & research, Cell culture, Embryonic stem cells, Stem cell research

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Sperm and mammalian polarity

Article Abstract:

Issues are presented concerning the influence which the position at which the egg of a mouse is fertilized by a sperm, has on the developing embryo's layout. The development of mammalian body pattern is discussed.

Developmental biology, Reproduction (Biology), Reproduction

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