Essential role for ZAP-70 in both positive and negative selection of thymocytes

Article Abstract:

A protein tyrosine kinase, ZAP-70, appears to mediate thymic selection for CD4 and CD8 lineage and is important for T-cell activation and development. ZAP-70 is expressed in both natural killer cells and T-cells and is associated with T-cell receptor signalling subunits. A ZAP-70 deficiency in humans results in no effective CD8 single-positive cells though CD4-nonfunctioning cells are unaffected possibly because Syk, a ZAP-70 homolog, mediates the selection of CD4 cells. In double negative ZAP-70 mice, neither CD4 nor CD8 were present.

T cell antigen receptors, Genetic regulation, Protein tyrosine kinase, Protein-tyrosine kinase, Cell receptors, T cells

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The murine gene p27kip1 is haplo-insufficient for tumour suppression

Article Abstract:

P27kip can inhibit cyclin-dependent kinases and stop cell proliferation. The p27 protein is found in abnormally low levels in human carcinomas, although a causal link between p27 and tumour suppression has not been possible. It has been shown that both p27 nullizygous and p27 heterozygous mice were predisposed to multiple tissue tumours when challenged with a chemical carcinogen or gamma-irradiation, indicating that P27 is a tumour suppressor in mice.

Proteins, Tumor suppressor genes

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A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

Article Abstract:

Research is presented concerning the inability of cells expressing p27T187A to downregulate p27 during the G2 and S phases of the cell cycle. The influence of this on in vivo and in vitro cell proliferation is discussed.

Physiological aspects, Cancer, Cell division, Proteolysis, Letter to the Editor

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