Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

Article Abstract:

Myogenesis in the diaphragm, limb buds and tongue tip involves the c-met-encoded receptor tyrosine kinase which regulates the migration of myogenic precursor cells while its scatter factor/hepatocyte growth factor is part of the control system of some embryonic cells' survival, migration and growth. Axial skeletal muscles, head muscles and the body wall do not involve the c-met receptor. This data is based on research involving double c-met negative mice and heterozygous c-met mice.

Analysis, Physiological aspects, Genetic aspects, Muscle cells, Cell research, Cytological research, Myogenesis

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Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

Article Abstract:

Experimental studies on mutant mice with a targeted disruption of hepatocyte growth factor/scatter factor (HGF/SF) gene reveal that allantoic mesenchyme-trophoblastic epithelia interaction, which is necessary for placental organogenesis, requires HGF/SF. Placentas are impaired in the homozygous mutant embryos and they have significantly reduced levels of labyrinthine trophoblast cells.

Trophoblast, Trophoblasts

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Scatter factor/hepatocyte growth factor is essential for liver development

Article Abstract:

Experimental studies on mice lacking scatter factor (SF)/hepatocyte growth factor (HGF) reveal that the development of various epithelial organs requires SF/HGF. This mutation decreases the size of the embryonic liver and the liver exhibits significant loss of parenchymal cells. Absence of SF/HGF leads to impairment of the development of the placenta.

Mice, Mice (Rodents), Animal anatomy

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