Essential role of Stat6 in IL-4 signalling

Article Abstract:

The signal transducer and activator of transcription-6 (Stat6) gene plays a crucial role in the biological responses induced by interleukin-4 (IL-4). The expression of CD23 and the major histocompatibility complex class II are unaffected by IL-4 in mutant mice deficient in Stat6. B-cell proliferation, that is stimulated by IL-4 and anti-IgM antibody, is suppressed in the mutants. The formation of Th2 cytokines from T cells and the responses of IgE and IgG1 after nematode infection decrease. The responses compare well with those observed in IL-4 deficient mice and in response to IL-4 antibodies.

Mutation (Biology), Mutation, Mice as laboratory animals, House mouse, Interleukin-4

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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

Article Abstract:

Pre-B-cell-growth-stimulating factor/stromal cell-derived factor-1 (PBSF/SDF-1), a member of the CXC group of chemokines, has an important physiological role in development. Mutant mice with disrupted gene encoding PBSF/SDF-1 die perinatally. The mutant embryos have reduced B-cell progenitors in both fetal liver and bone marrow, while they have reduced myeloid progenitors only in the bone marrow. This indicates that PBSF/SDF-1 regulates B-cell lymphopoiesis and bone-marrow myelopoiesis. The mutants also have a cardiac ventricular septal defect.

Analysis, Bone marrow, Mice, mutant strains, B cells, Mutant mice

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Structure and function of a new STAT-induced STAT inhibitor

Article Abstract:

JAK kinases and STAT (signal transducer and activator of transcription) proteins combine to form a signalling pathway that is important for relaying signals between cytokines inside and outside the cell. The mechanism responsible for turning off the cytokine signals is not fully understood. A new STAT-induced STAT inhibitor, named SS-1, has been cloned and research shows that its messenger RNA is induced by leukaemia-inhibitory factor, cytokine interleukins 4 and 6, and granulocyte colony-stimulating factor.

Cell receptors, Cell research, Cytological research

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