Evidence for cooperative interactions in potassium channel gating

Article Abstract:

The gating of the potassium ion channels (K+-channels) occurs cooperatively between the different subunits instead of separately. This was determined by constructing complementary DNA for the four subunits and specifying the subunit stoichiometry on a single polypeptide chain. The gating of heterotetramers composed of combinations of subunits indicated that the subunits open up together rather than independently. Nonindependent gating agrees with what is known about K+-channel kinetics.

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Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation

Article Abstract:

Atrial natriuretic peptide (ANP) uses protein dephosphorylation to initiate calcium- and voltage-activated potassium channel (BK) activity in GH4C1 cells. In addition, ANP differs from another natriuretic peptide, somatostatin, by requiring cyclic guanosine monophosphate (cGMP) and cGMP-dependent protein kinase activity before BK can start to function. Hence ANP regulates electrophysiology by limiting calcium channels in favor of BK.

Physiological aspects, Cyclic guanylic acid, Cyclic guanosine monophosphate, Electrophysiology, Natriuretic peptides

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Fifty years of inactivation

Article Abstract:

New research, revealing the events involved in the closure of potassium channels, known as inactivation, is discussed.

Cell interaction

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