Arterial hardening in mice

Article Abstract:

The risk factors for human atherosclerosis are well known, but with one exception until now its etiology has been difficult to establish. A study using transgenic mice expressing human apolipoprotein(a) shows that on high-fat diets those mice develop atherosclerosis. Other studies that knock out certain genes encoding components involved in lipid transport in the blood have had similar results. The transgenic mice developed a form of atheroma similar to the human disease in which lipid-rich fibrous plaques are developed.

Genetic aspects, Arteriosclerosis, Medical genetics

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Good cholesterol news

Article Abstract:

Three groups have studied patients with Tangier disease, a rare, recessive disorder, characterized by the reduced efflux of cholesterol from cells. They found that the disease is due to defects in an ATP-binding-cassette (ABC) transporter gene encoding the cholesterol-efflux regulatory protein (CERP). This discovery provides information on high-density lipoprotein metabolism and opportunities for the prevention of heart attacks and drug discovery.

Prevention, Heart diseases, Cholesterol

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