Function of Rieger syndrome gene in left-right asymmetry and craniofacial development

Article Abstract:

Research into Rieger syndrome, an autosomal dominant disorder, has involved using gene targeting in mice to produce a loss-of-function allele that would be forecast to result in organ randomization or isomerization. Pitx2-/- embryos had abnormal cardiac morphogenesis, but mutant hearts were found to loop in the normal direction. Loss of pitx2 function was found to lead to right pulmonary isomerization. This supports previous suggestions that pitx2 provides leftness to the pulmonary primordia. It is possible that pitx2 regulates local cell signalling during asymmetric morphogenesis.

Genetic aspects, Birth defects

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The origin of spinifex texture in komatiites

Article Abstract:

Many komatiites occured as subaqueous lava flows, and their spinifex texture is a characteristic feature. Evidence is provided that this texture developed due to large thermal gradients, together with conductive and radiative heat transfer in olivine crystals. This is often associated with high-temperature techniques used to grow synthetic crystals, but is not often considered in geological contexts.

Research, Komatiite

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