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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

Article Abstract:

A combination of high-resolution, single-nucleotide polymorphism arrays and genomic DNA sequencing is employed to perform a genome-wide analysis of genetic alterations of leukaemic cells in acute lymphoblastic leukaemia (ALL). The analysis reveals that the direct disruption of pathways that control the B-cell development leads to B-progenitor ALL pathogenesis, which is then used to identify and study new molecular lesions in cancer.

Author: Relling, Mary V., Evans, William E., Mathew, Susan, Downing, James R., Ching-Hon Pui, Jing Ma, Mullighan, Charles G., Goorha, Salil, Radtke, Ina, Miller, Christopher B., Coustan-Smith, Elaine, Dalton, James D., Girtman, Kevin, Pounds, Stanley B., Xiaoping Su, Shurtleff, Sheila A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Acute lymphocytic leukemia, Nucleotide sequencing, Single nucleotide polymorphisms

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Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange

Article Abstract:

Mutations in Dmc1 (disrupted meioses cDNA1) cause no discriminible mitotic phenotype but lead to a constellation of meitotic abnormalities. Human Dmc1 protein (hDmc1) is examined for the ability to promote DNA strand exchange, and show that hDmc1 mediates strand exchange between paired DNA substrates over at least several thousand base pairs.

Author: Sung, Patrick, Bussen, Wendy, Sehorn, Michael G., Sigurdsson, Stephan, Unger, Vinzenz M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Meiosis

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Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome

Article Abstract:

The identification of a missense mutation (T44A) in the human casein kinase I (CKI)delta gene, which results in familial advanced sleep phase syndrome, is reported. Transgenic Drosophila carrying the human CKIdelta-T44A gene showed a phenotype with lengthened circadian period.

Author: Ptacek, Louis J., Shapiro, Robert E., Xu, Ying, Padiath, Quasar S., Jones, Christopher R., Saigoh, Noriko, Wu, Susan C., Saigoh, Kazumasam, Ying-Hui Fu
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Sleep disorders

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Subjects list: Research, United States, Gene mutations, Gene mutation, Genetic aspects
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