Gli/Zic factors pattern the neural plate by defining domains of cell differentiation

Article Abstract:

All Zic proteins appear to recognize Gli binding sites. A nuclear protein is encoded by frog Zic2. Tests were undertaken to determine whether Zic2 is involved in defining neurogenic domains. The expression patterns of N-tubulin (N-tub) and Neurogenin1 (Ngnr1) were analyzed in injected embryos. Misexpression of Zic2 led to the unilateral loss of N-tub and Ngnr1. Neurogenesis suppression was found not to be due to inhibition of neural development. Zic2 is concluded to be a vertebrate pre-pattern gene.

Observations, Developmental neurology, Nerve proteins, Nerve tissue proteins

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RGS10 is a selective activator of G-alpha(sub i) GTPase activity

Article Abstract:

The human regulators of G-protein signaling 10 (RGS10) subunit increases the GTP hydrolytic activity of proteins of the G-alpha(sub i) family. The human RGS10 selectively activates GTPase G-alpha(sub i3) and G alpha (sub z) subunits. It fails to activate the G alpha (sub s) subunits which are structurally and functionally distinct. The results of the study shows that the polypeptide decreases heterotrimeric G-protein signaling pathways by activating G alpha GTPase.

Guanosine triphosphatase

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