ICAM-2 redistributed by ezrin as a target for killer cells
Article Abstract:
Transfection of the human cytoskeletal-membrane linker protein ezrin into natural killer (NK) resistant cells provides evidence of target cell recognition through cytotoxic cells. These cells recognize adhesion molecules in both normal as well as diseased cells, and the transfection redistributes the intercellular adhesion molecule ICAM-2. The transfection also creates bud-like cellular projections called uropods. ICAM-2 sensitizes target cells to interleulin-2-activated killing and the level of its expression in NK-sensitive and resistant cells is quite similar.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Self-recognition by proteoglycans
Article Abstract:
The evolution of multicellular life forms depended on the aggregation of groups of similar cells. A mechanism by which disaggregated sponge cells stick to cells of similar species through cell-surface proteoglycans was described. These sponge proteoglycans may represent the type of cell-surface molecules necessary to form multicellular organisms since they provide the key recognition and adhesion functions. These molecules may have also been responsible for the further divergence of species and the appearance of more complex multicellular forms of life.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Lipid-cytoskeleton interactions
Article Abstract:
Acidic phospholipid phosphatidylinositol 4,5-bisphosphate (PtdInsP2) needs alpha-actinin based on the observation that PtdInsP2 stays attached to alpha-actinin despite SDS-PAGE and nitrocellulose transfer. This finding, which pertains to how lipids interact with the cytoskeletal protein vinculin, lacks supportive evidence. The rebuttal view is that such evidence does exist. An example is the discovery that striated muscle tissue contains both PtdInsP2 and alpha-actinin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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