Glutamate receptors put in their place

Article Abstract:

Glutamate is the main excitatory neurotransmitter in mammalian brain that binds to and activates several classes of postsynaptic receptor. Neurotransmission depends on where the different kinds of receptor are concentrated. NMDA receptors bind to the PSD-95/SAP90 family of synaptic proteins while AMPA receptor subunits bind to a novel synaptic protein called glutamate receptor interacting protein. Meanwhile, a protein called Homer has been isolated which binds to a subset of metabotropic glutamate receptors.

Research, Glutamate, Neural transmission, Synaptic transmission

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Improving enzyme-electrode contacts by redox modification of cofactors

Article Abstract:

An approach that allows site-specific positioning of electron-mediating units in redox proteins has been developed. The technique involves stripping glucose oxidase of its flavin adenine dinucleotide (FAD) cofactors and restructuring the latter with redox-active ferrocene-containing groups, then reconstituting the apoprotein with these modified cofactors. This allows highly enhanced electrical interaction between an electrode and the resulting enzyme in solution.

Usage, Apoprotein, Apoproteins

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Influence of TOR kinase on lifespan in C. elegans

Article Abstract:

TOR kinases (target of rapamycin) is a group of enzymes which regulates cell growth and proliferation in response to nutrients and hormone- dependent mitogenic signals. TOR deficiency in the nematode Caenorhabditis elegans more than doubling its natural lifespan is shown.

Evaluation, Influence, Rapamycin

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