HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

Article Abstract:

It has been possible to demonstrate Nef-mediated major histo-compatability complex class I down-regulation and protection from cytotoxic T lymphocytes (CTLs) in primary CD4+ lymphocytes from eight different donors. The observed protection ranges from 2- to 34-fold, according to the level of cytotoxicity of the CTLs. It was found that nef has a significant impact on surface class I in primary cells and has functional importance because nef protects infected cells from anti-HIV CTL recognition.

Cell-mediated cytotoxicity, Cell mediated cytotoxicity

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Modelling T-cell memory by genetic marking of memory T cells in vivo

Article Abstract:

Immunological memory allows the immune system to respond more vigorously to previously encountered pathogens. Most T cells undergo cell death following infection although some persist as a pool of memory T cells. A transgenic mouse model system was developed where memory T cells were marked with a reporter gene and could be identified.

Immunologic memory

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Investigating T-cell memory

Article Abstract:

An investigation of T-cell memory is presented.

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