How does variation count?

Article Abstract:

Recent research on the variation and evolution of viruses was the subject of an EMBO workshop held in Grignon, France from Jul 7 to Jul 11, 1992. Participants learned of new techniques for studying viral diseases and how viruses evolve into new varieties. Complicated but usable experimental viral systems were described that could verify or falsify current theories of viral population dynamics. In addition, participants learned that not only the human immunodeficiency virus but all RNA viruses have high rates of mutation and recombination.

Conferences, meetings and seminars, Viruses, Evolution (Biology), Viral genetics, Virology

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Closing the joint

Article Abstract:

It has been established that a cellular damage-sensing system is implicated in completing retroviral integration. This research involved seeking to infect cells defective in a damage-sensing protein complex with a number of different retroviral vectors. It was concluded that DNA-dependent protein kinase (DNA-PK) is required to complete integration, probably through repairing the gapped DNA left by integrase. The theory that DNA-PK is directly involved in integration has attracted controversy.

Retroviruses

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Lines drawn in epitope wars

Article Abstract:

A study of the host immune response in coping with HIV infection and the cytotoxic T cells response in two infected haemophiliacs shows that the HIV virus was bonded to a single epitope for one patient but for the other patient, a complex figure of shifting immunodominance with the coming and disappearing variant viruses is detected. For the first patient the disease development is slow which likely relates to a fruitful response against a comparatively constant epitope.

HIV infection, HIV infections, Cell-mediated cytotoxicity, Cell mediated cytotoxicity, Immune response, Antigenic determinants, Immune response regulation

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