Identification by mutagenesis of a Mg2+-block site of the NMDA receptor channel

Article Abstract:

The ability of Mg2+ to stop the the N-methyl-D-aspartate's (NMDA) permeation to Ca2+ is diminished by inserting glutamine in place of asparagine 598 in the zeta-a subunit of NMDA's putative transmembrane segment M2. Another NMDA subunit, epsilon-2, acts on Mg2+ in a similar way. The heteromeric epsilon-2/zeta-1 NMDA receptor channel with mutations is also less sensitive to the MK-801 channel blocker than NMDA without the mutations. These results indicate that the conserved asparagine residue in segment M2 is a Mg2+-block site of NMDA's receptor channel with MK-801 extending into the Mg2+ site.

Usage, Mutagenesis, Magnesium in the body, Magnesium (Nutrient)

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Distinct components of spatial learning revealed by prior training and NMDA receptor blockade

Article Abstract:

D(-)-2-amino-5-phosphonovaleric acid (AP5) inhibits learning and memory by antagonizing the N-methyl-D-aspartate (NMDA) receptor in rats. The inhibitory effect of this antagonist on the hippocampal long-term potentiation and spatial learning is eliminated by pretraining the rats in a different watermaze. Pretraining of the rats with a non-spatial learning does not improve the learning impairment caused by AP5. This indicates that the NMDA receptors may not be associated with the encoding of spatial representation of individual environments.

Learning, Observations, Hippocampus (Brain), Animals, Training of, Animal training, Rats as laboratory animals, Laboratory rats

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The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

Article Abstract:

Ionotropic glutamate receptors are classified into NMDA and AMPA receptors. AMPA receptors are reported to act as cell-surface signal transducers as wll as ion channels, by way of interaction with the non-receptor protein tyrosine kinase Lyn. Lyn is linked with the AMPA receptor in the cerebellum and its activation is independent of Ca(super2+) and NA+ influx via AMPA receptors. AMPA receptors generate intracellular signals to the nucleus from the cell surface via the Lyn-MAPK route.

Glutamate, Protein tyrosine kinase, Protein-tyrosine kinase

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